
Image: PDF on an iPhone (Click image to enlarge.)
PDF is designed to reproduce page images. PDF text traditionally could not be re-flowed to fit the screen width or size. As a result PDF files designed for printing on standard paper sizes are less easily viewed on screens with limited size or resolution, such as those found on mobile phones and PDAs. Adobe has addressed this by adding a re-flow facility to its Acrobat Reader software, but for this to work the document must be marked for re-flowing at creation, which means that existing PDF documents will not benefit unless they are tagged and resaved.
PDF documents can be read on an iPad. That is great for access to legacy and transitional documents. But, if you are hoping to have your eBook reach a larger audience, consider EPUB.

Image: EPUB on an iPhone (Click image to enlarge.)
A great source for much of this post and recommended reading is Elizabeth Castro's great book, EPUB Straight to the Point: Creating ebooks for the Apple iPad and other ereaders, published by Peachpit Press in both print and electronic editions.
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